![]() ![]() Read more about how to correctly acknowledge RSC content. If you think JDownloader is too old for your modern PC, you should check out the Motrix download manager. Permission is not required) please go to the Copyright If you want to reproduce the wholeĪrticle in a third-party commercial publication (excluding your thesis/dissertation for which If you are the author of this article, you do not need to request permission to reproduce figuresĪnd diagrams provided correct acknowledgement is given. Provided correct acknowledgement is given. If you are an author contributing to an RSC publication, you do not need to request permission Please go to the Copyright Clearance Center request page. To request permission to reproduce material from this article in a commercial publication, Provided that the correct acknowledgement is given and it is not used for commercial purposes. This article in other publications, without requesting further permission from the RSC, Chaker,Ĭreative Commons Attribution-NonCommercial 3.0 Unported Licence. The release rate depends on intramolecular matrix–matrix and intermolecular drug–matrix interactions, as well as a crystalline state of the matrix.ĭrug dual-release matrix proprieties and the correlations with nanostructure aggregation kinetics for siloxane-polyether/hydrogel nanocomposites These dependencies were found to be correlated to the physical and chemical properties of the nanocomposites, including the interactions disturbing polycondensation formation. The first is in the early stages of drug release, governed by erosion, diffusion and swelling and the second, in advanced stages of release, typical of diffusion through pores. The release behaviour was determined to be composed of two concomitant release mechanisms. The variation of the different types of hydrogels, bis-acrylamide (BIS), poly(acrylamide- co-acrylic acid) (PAM) and polyvinylpyrrolidone (PVP) can modify the drug release profiles. ![]() For in vitro release tests Piroxicam was used as a model molecule. The interactions between matrix and drug were examined by infrared spectroscopy to verify the compatibility of the drug with the matrix. The nanostructure was studied with small-angle X-ray scattering (SAXS) to determine the siloxane nanostructure aggregation mechanisms. The influence of hydrogels on the nanostructural formation of siloxane-polyether nanocomposites was examined. ![]()
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